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Dean G Assimos

All articles from this author are listed below.

Volume 9, Number 3 Meeting Reviews

Best of the 2007 AUA Annual Meeting

Meeting Review

J Curtis Nickel Jacob Rajfer Claus G Roehrborn Michael K Brawer Dean G Assimos Danil V Makarov Ellen Shapiro Alan W Partin Michael B Chancellor

Highlights from the 2007 Annual Meeting of the American Urological Association May 19-24, 2007 Anaheim, CA [Rev Urol. 2007;9(3):133-154]

Prostate cancer Obesity Benign prostatic hyperplasia Antibiotic prophylaxis Nocturia Lower urinary tract symptoms Botulinum toxin Prostate-specific antigen Biomarkers PCA3 Testosterone Urinary tract infections Urolithiasis Laser ablation Endourology Male voiding dysfunction LHRH antagonists Antimuscarinic agents Circumcision Repeat biopsy Human glandularkallikrein Expectant management CRISP-3 MSP Microvesseldensity Endoglin Survivin Telomeres Interleukin-8 PDE-5 inhibitors Acute urinaryretention 5Alpha-reductase inhibitors Doxazosin Finasteride Transurethral microwave thermotherapy TURP Perioperative blood loss Microbialbiofilms HIV Stem cell injection

Volume 9, Number 1 Review Articles

Uric Acid Nephrolithiasis: Recent Progress and Future Directions

Management Update

Tin C Ngo Dean G Assimos

The prevalence of urolithiasis has been increasing for the past few decades in industrialized nations. Uric acid calculi account for a significant percentage of urinary stones. Certain risk factors may be involved in the pathogenesis of uric acid nephrolithiasis, including hyperuricosuria, low urinary volume, and persistently low urinary pH. Patients with medical conditions that promote profound hyperuricosuria are at high risk of developing uric acid calculi. These conditions include chronic diarrheal states; myeloproliferative disorders; insulin resistance, including diabetes mellitus; and monogenic metabolic disorders, such as Lesch-Nyhan syndrome. Computed tomography can provide a definitive diagnosis. Except in cases in which there is severe obstruction, progressive azotemia, serious infection, or unremitting pain, the initial treatment of patients with uric acid nephrolithiasis should be medical dissolution therapy because this approach is successful in the majority of cases. A thorough review of the epidemiology and pathophysiology of uric acid nephrolithiasis is crucial for the diagnosis, treatment, and prevention of stones in patients with this condition. [Rev Urol. 2007;9(1):17-27]

Urolithiasis Uric acid nephrolithiasis Hyperuricosuria Gout

Volume 10, Number 3 Review Articles

Hypercalcemic States Associated With Nephrolithiasis

Management Update

Corey Passman Brandon L Craven Dean G Assimos

Although kidney stone formation due to hypercalcemic states is rare, it is important for urologists to understand the pathophysiology of these conditions, methods of diagnosis, and treatments. This should foster a quicker diagnosis and institution of appropriate therapy. The latter typically leads to the attenuation of kidney stone activity. Moreover, these patients have a systemic disease, and therapy has other health benefits. [Rev Urol. 2008;10(3):218-226]

Nephrolithiasis Vitamin D Sarcoidosis Hypercalcemia Calcium homeostasis Calcitriol Parathyroid hormone Hyperparathyroidism

Volume 11, Number 3 Review Articles

Hypocitraturia: Pathophysiology and Medical Management

Management Review

Dean G Assimos Jack M Zuckerman

Low urinary citrate excretion is a known risk factor for the development ofkidney stones. Citrate inhibits stone formation by complexing with calciumin the urine, inhibiting spontaneous nucleation, and preventing growth andagglomeration of crystals. Hypocitraturia is a common metabolic abnormalityfound in 20% to 60% of stone formers. It is most commonly idiopathic inorigin but may be caused by distal renal tubular acidosis, hypokalemia, boweldysfunction, and a high-protein, low-alkali diet. Genetic factors, medications,and other comorbid disorders also play a role. Hypocitraturia should be managedthrough a combination of dietary modifications, oral alkali, and possiblylemonade or other citrus juice–based therapy. This review concerns thepathophysiology of hypocitraturia and the management of stone formersafflicted with this abnormality.[Rev Urol. 2009;11(3):134-144 doi:10.3909/riu0424]© 2009 MedReviews®, LLC

Hypocitraturia Citrate metabolism Citrate pathophysiology Hypocitraturia etiologies Medical management of stone disease Alkali citrate Potassium citrate Citrus juice Lemonade

Volume 11, Number 2 Meeting Reviews

Best of the 2009 AUA Annual Meeting

Highlights From the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL

Claus G Roehrborn Michael K Brawer Naoki Yoshimura J Curtis Nickel Arie S Belldegrun B Shuch F Pouliot Ellen Shapiro Dean G Assimos Alan W Partin Michael B Chancellor Stacy Loeb

Prostate cancer screening Obesity Benign prostatic hyperplasia Lower urinary tract symptoms Vesicoureteral reflux Nephrolithiasis Stress urinary incontinence Inflammation Silodosin Hormonal therapy Tumor markers TMPRSS2ERG 4-Kallikrein panel Botulinum toxin type A Male voiding dysfunction Benign prostatic specific antigen Roux-en-Y gastric bypass surgery Genitourinary pain index UPOINT clinical phenotype system Nephron-sparing surgery Watchful waiting Laparoscopy for adrenal cortical carcinoma Partial adrenalectomy Urethral trauma Pediatric urethral stricture Enteric urologic surgery

Volume 12, Number 3 Literature Reviews

Reviewing the Literature

Volume 12, Number 1 Case Review

Transitional Cell Carcinoma Within a Calyceal Diverticulum Associated With Stone Disease

Case Review

Corey Passman Dean G Assimos Jack M Zuckerman

We report a case of transitional cell carcinoma (TCC) discovered within a calyceal diverticulum at the time of percutaneous nephrolithotomy. The stones and tumor were endoscopically removed and the diverticular cavity fulgurated. Pathologic analysis demonstrated low-grade TCC. A subsequent laparoscopic radical nephroureterectomy was performed and high-grade TCC invading the parenchyma was found. This case demonstrates the potential for TCC to develop in stone-containing calyceal diverticula and also the potential for coexistence of different grades of TCC within the involved renal unit.[Rev Urol. 2010;12(1):52-55 doi: 10.3909/riu0446]

Percutaneous nephrolithotomy Urinary tract infection Transitional cell carcinoma Urolithiasis Calyceal diverticulum Stone

Volume 13, Number 4 Review Articles

Changing Patterns in Iatrogenic Ureteral Injuries

Treatment Review

Victoriano Romero Haluk Akpinar John Smith III Dean G Assimos

Advances in laparoscopic and endoscopic surgery over the past 25 years have changed the preferred methods for performing many operations. We previously reported an increase in the number of patients treated for ureteral injury at our institution that paralleled the introduction of minimally invasive techniques. Since that report, more advanced endoscopic procedures have been introduced. We sought to determine whether the latter influenced the number of ureteral injuries managed at our institution. Reported here are the results of our retrospective study, which sought to determine if the rate of treatment of major iatrogenic ureteral injuries has changed. [Rev Urol. 2011;13(4): e179-e183 doi: 10.3909/riu0537] © 2011 MedReviews®, LLC

Ureteroscopy Ureteral injury Laparoscopic cholecystectomy Proximal ureter Renal salvage