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Focal therapy

All articles from this key word are listed below.

Volume 11, Number 4 Review Articles

Focal Therapy: A New Paradigm for the Treatment of Prostate Cancer

Treatment Update

Guilherme Godoy Basir Tareen Samir S Taneja

Focal therapy has been proposed in recent years as a means of bridging the gap between radical prostatectomy and active surveillance for treatment of prostate cancer. The rationale for focal therapy comes from its success in treating other malignancies. One of the challenges in applying such an approach to the treatment of prostate cancer has been the multifocal nature of the disease. This review addresses the selection of potentially ideal candidates for focal therapy and discusses which modalities are currently being used and proposed for focal therapy. Setting and meeting guidelines for oncologic efficacy is a challenge we must embrace to safely deliver this potentially revolutionary approach to treating men with prostate cancer.[Rev Urol. 2009;11(4):203-212 doi: 10.3909/riu0475]© 2009 MedReviews®, LLC

Prostatic neoplasms Focal therapy Prostate-specific antigen Prostatectomy Photodynamic therapy Ultrasound, high-inten sity focused, transrectal Cryosurgery

Volume 13, Number 2 Meeting Reviews

New Frontiers in Imaging and Focal Therapy

Highlights From the Third International Symposium on Focal Therapy and Imaging of Prostate and Kidney Cancer, February 24-27, 2010, Washington, DC

Thomas J Polascik Vladimir Mouraviev

[Rev Urol. 2011; 13(2):104-111 doi: 10.3909/riu0523] © 2011 MedReviews®, LLC

Prostate cancer Focal therapy Kidney cancer

Volume 16, Number 2 Review Articles

Focal Laser Ablation for Localized Prostate Cancer: Principles, Clinical Trials, and Our Initial Experience

Treatment Update

Dan Sperling Neil Mendhiratta Ted Lee Herbert Lepor

Focal therapy of prostate cancer is an evolving treatment strategy that destroys a predefined region of the prostate gland that harbors clinically significant disease. Although long-term oncologic control has yet to be demonstrated, focal therapy is associated with a marked decrease in treatment-related morbidity. Focal laser ablation is an emerging modality that has several advantages, most notably real-time magnetic resonance imaging (MRI) compatibility. This review presents the principles of laser ablation, the role of multiparametric MRI for delineating the site of significant prostate cancer, a summary of published clinical studies, and our initial experience with 23 patients, criteria for selecting candidates for focal prostate ablation, and speculation regarding future directions. [Rev Urol. 2014;16(2):55-66 doi: 10.3909/riu0615] © 2014 MedReviews® LLC

Prostate cancer Focal therapy Targeted therapy Laser ablation

Volume 19, Number 4 Case Review

Irreversible Electroporation for Prostate Cancer as Salvage Treatment Following Prior Radiation and Cryotherapy

Jonathan A Coleman Oguz Akin Katie S Murray

Salvage treatment options after localized primary treatment failure of prostate cancer are limited and associated with risk for serious complications. We report on the management details of a 57-year-old African American man treated with partial-gland ablation using irreversible electroporation following local recurrence after brachytherapy and prior salvage cryoablation. Therapeutic and functional outcomes were assessed by conventional means, including serum prostate-specific antigen values and prostate biopsy results. [Rev Urol. 2017;19(4):268–272 doi: 10.3909/riu0755] © 2018 MedReviews®, LLC

Prostate cancer Focal therapy Irreversible electroporation Salvage therapy

Volume 21, Number 4 Meeting Reviews

Prostate Cancer Academy 2019 Selected Summaries

[Rev Urol. 2019;21(4):166–171] © 2020 MedReviews®, LLC

Prostate cancer Immunotherapy Active surveillance Focal therapy mpMRI PSMA-PET