Volume 16, Number 3Review ArticlesRole of Chemokines in Renal Cell CarcinomaSystematic ReviewJaspreet S PariharHari Siva Gurunadha Rao TunuguntlaWith new frontiers of pharmaceutical therapies focusing on tumor growth and angiogenesis, understanding the interaction between immune system and tumor microenvironment has become ever more important. Chemokines and chemokine receptors appear to play an integral role in tumor characteristics. Evidence suggests CXCR4, CXCL5, CXCR7, and stromal derived factor-1 appear to be crucial in survival, growth, and metastasis of renal cell carcinoma. As the role of chemokines in renal cancer is becoming more evident, further research will lead to a better understanding of tumor biology and the development of new therapeutic targets to help improve survival. [Rev Urol. 2014;16(3):118-121 doi: 10.3909/riu0608] © 2014 MedReviews®, LLCRenal cell carcinomaCytokinesChemokineOncocytoma