Issues

Management of Overactive Bladder With Transdermal Oxybutynin

Treatment Update

Roger R DmochowskiJonathan S Starkman

In clinical trials, transdermal oxybutynin (OXY-TDS) has shown comparable efficacy and improved tolerability when compared with conventional pharmacotherapy. Systemic anticholinergic adverse effects are comparable to those with placebo, most likely owing to avoidance of first-pass hepatic metabolism and conversion of oxybutynin to N-desethyloxybutynin. OXY-TDS has predictable pharmacokinetic absorption and elimination parameters, as shown in both in vitro and in vivo studies. Consistent plasma concentrations of oxybutynin avoid labile peak and trough concentrations seen with immediaterelease formulations, paralleling extended-release drug delivery. This novel drug delivery system has unique dermatologic skin application site reactions, including erythema and pruritus. Skin reactions are usually mild and can be minimized by varying the site of patch application. Most eczematous dermatologic reactions can be appropriately treated with a moderately potent topical corticosteroid cream. A small percentage of patients will discontinue therapy as a result of bothersome application site skin reactions. [Rev Urol. 2006;8(3):93-103]

16th International Prostate Cancer Update

Introduction

Michael K Brawer

Erectile Function Outcomes in the Current Era of Anatomic Nerve-Sparing Radical Prostatectomy

Therapeutic Challenges

Arthur L Burnett

The contemporary use of anatomic nerve-sparing radical prostatectomy, which entails preserving the autonomic nerve supply to the penis required for penile erection, has led to improved erectile function outcomes compared with what has been seen historically. However, delay of postoperative recovery of erection for as long as 2 years is common, such that dysfunctional erection status lingers as a major postoperative problem. Several possible strategies to improve overall recovery rates and to hasten postoperative recovery of erectile function are currently being advanced. These include pharmacologic rehabilitation therapy and neuromodulatory therapy. Rigorous basic scientific investigation and clinical assessment of these new strategic approaches are critically important to establish their actual therapeutic benefits. [Rev Urol. 2006;8(2):47-53]

The Evolving Role of Imaging in Identification and Management of Prostate Cancer

Introduction

David G McLeod

Surveillance Strategies for Renal Cell Carcinoma Patients Following Nephrectomy

Management Update

Arie S BelldegrunArnold I ChinRobert A FiglinJohn S Lam

Update on the Use of Interstitial Laser Coagulation in the Treatment of Benign Prostatic Hyperplasia

Introduction

Michael K Brawer

BPSA: A Novel Serum Marker for Benign Prostatic Hyperplasia

Kevin M SlawinShahrokh F ShariatEduardo I Canto

Factors in Predicting Failure With Medical Therapy for BPH

Steven A Kaplan

Bladder Outlet Obstruction: Etiology and Evaluation

Roger R Dmochowski

Comparison of Single-Agent Androgen Suppression for Advanced Prostate Cancer

Herbert Lepor