EditorialFailing to Prepare Is Preparing to FailKathleen A LatinoDeepak A Kapoor[Rev Urol. 2020;22(3):91-92] © 2020 MedReviews®, LLC
Review ArticlesThe Impact of Systematic Safety Precautions on COVID-19 Risk Exposure and Transmission Rates in Outpatient Healthcare WorkersChiraag PatelMarcus CognettiJonathan AndersonGillian HodesAnn E AndersonKathleen LatinoDeepak A KapoorWe evaluated the impact of safety protocols, including rapid testing and contact tracing, on coronavirus disease 2019 (COVID-19) risk exposure and transmission rates amongst healthcare workers in the outpatient care setting. Over an 11-week period, a total of 254 employees representing 38% of our total workforce had potential COVID-19 exposure and underwent voluntary COVID-19 testing. Data was stratified based on severity of risk exposure and job description. During this period, the probability of a COVID exposure being high risk decreased in Administrative (293.0%; P < 0.01) and Clinical (277.0%; P < 0.01) staff; simultaneously, viral transmission rates declined in Administrative (273.4%; P = 0.03) and Clinical (269.9%; P = 0.04) staff as well. Systematic safety protocols effectively reduce exposure risk and transmission rates in outpatient healthcare workers and should be ubiquitously adopted. [Rev Urol. 2020;22(3):93-101] © 2020 MedReviews®, LLCSafetyCOVID-19 diagnostic testingContact tracing
Review ArticlesA Trend Toward Aggressive Prostate CancerOriginal ResearchNavin ShahVladimir IoffeTo compare prostate biopsy (Pbx) characteristics before and after the 2012 United States Preventive Services Task Force (USPSTF) prostate cancer (PCa) screening guidelines, we completed a retrospective comparative analysis of 1703 sequential patients that had a Pbx in 2010 to 2012 (3 years) with 383 patients biopsied in 2018 and 310 patients biopsied in 2019. Data was collected on patient age, race, serum prostate specific antigen (PSA) level, digital rectal examination (DRE) results, total number of biopsies performed, and Gleason sum score (GSS). Data were analyzed to determine whether the 2012 USPSTF screening recommendations against PCa screening may have affected PCa characteristics. Three study groups were defined as Group A, Group B, and Group C. Group A represents Pbx prior to the 2012 USPSTF screening guidelines (2010-2012), Group B represents Pbx in 2018, and Group C represents Pbx in 2019. The patient population consisted of 73% Black men, 16% White men, and 11% men of other races. The number of patients that had a biopsy in Groups A through C, respectively, were 567 patients/year, 383 patients/year, and 310 patients/year. The annual positive Pbx rate for Group A through C was 134/year, 175/year, and 201/year, respectively. High-grade PCa (GSS 7-10) in Groups A through C was 51.5%, 60.5%, and 60.0%. The proportion of patients with a serum PSA level 10 ng/mL or greater in Groups A through C was 25.4%, 29.3%, and 33%. For patients age 70 to 80 years, there was an increasing trend for serum PSA levels 10 ng/mL and higher: 31%, 38%, and 39%, respectively. In this age group, high-grade tumors (GSS 7-10) occurred in 61%, 65%, and 68%, respectively. In 2019, Grade Group 3, 4, and 5 was present in 37.7% of 70- to 80-year-old men and 34.6% of Black men. More than 50% positive biopsy cores were present in 46.3% of 70- to 80-year-old men and 36.6% of Black men. Our data through 2019 continued to show that after the 2012 USPSTF recommendations against PCa screening, PCa screening has decreased. We found decreased Pbx, increased PCa diagnosis, and increased high-grade PCa (GSS 7-10). As our patient population consisted of 73% Black patients and 33% of men age 70 to 80 years, our results support aggressive PCa screening for high-risk patients, which include Black men, men with a family history of PCa, and healthy men age 70 to 80 years. [Rev Urol. 2020;22(3):102-109] © 2020 MedReviews®, LLCProstate cancerElderly menUnited States Preventive Services Task ForceProstate-specific antigen screeningBlack men
Review ArticlesCurrent and Future Management of Locally Advanced and Metastatic Prostate CancerOriginal ResearchNeal D ShoreWith increasing treatment options available, the management of locally advanced and metastatic prostate cancer (PCa) is growing more complex, nuanced, and individualized. Strategies for combining surgery, radiation, chemotherapy, and androgen deprivation therapy (ADT) continue to evolve, as do ADT and immunotherapy options. Additionally, multiple adjunctive agents for metastatic PCa have been recently approved or are pending approval. As the number of locally advanced and metastatic prostate cancers being diagnosed rises, so does the need to consider patients’ clinical situations and personal preferences. This review discusses current and potential future approaches to managing locally advanced and metastatic PCa. [Rev Urol. 2020;22(3):110-123] © 2020 MedReviews®, LLCProstate cancerChemotherapyAndrogen deprivation therapyMetastatic prostate cancerLocally advanced prostate cancer
LUGPA NewsVirtual Reality…COVID-styleRichard Gerald Harris[Rev Urol. 2020;22(3):124-125] © 2020 MedReviews®, LLC
Case ReviewFrom Radical to Partial Nephrectomy in the Setting of Solitary Functioning Kidney: Neoadjuvant Treatment of Renal Cell CarcinomaDavid D WatsonA J FarhaShaker DakhilK James KallailNicole G FarhaImmunotherapy has revolutionized the treatment of metastatic renal cell carcinoma (RCC). This case evaluates the use of neoadjuvant immunotherapy for localized RCC in a patient with solitary functioning kidney. A retrospective chart review was conducted between September 2019 and January 2020 on a single patient. Before treatment, the tumor was 7 cm × 8 cm × 8.5 cm. The patient trialed nivolumab + ipilimumab then cabozantinib. The tumor shrunk to 6.3 cm × 5.5 cm and was removed via partial nephrectomy. This case demonstrates the efficacy of immunotherapy in neoadjuvant treatment of RCC. Expansion of guidelines could allow for patients with RCC to undergo partial nephrectomy. [Rev Urol. 2020;22(3):126-129] © 2020 MedReviews®, LLCRenal cell carcinomaImmunotherapyNeoadjuvant immunotherapySolitary kidney
NYU Case of the MonthThe Role of Varicocelectomy and Diagnostic Testis Biopsy in Men With Non-obstructive AzoospermiaNYU Case of the Month, July 2020Bobby B Najari[Rev Urol. 2020;22(3):130-132] © 2020 MedReviews®, LLC
NYU Case of the MonthManagement of Urethral Stenosis After Treatment for Prostate CancerNYU Case of the Month, August 2020Lee C Zhao[Rev Urol. 2020;22(3):133-134] © 2020 MedReviews®, LLC
NYU Case of the MonthPercutaneous Management of Calyceal DiverticulumNYU Case of the Month, September 2020Philip T Zhao[Rev Urol. 2020;22(3):135-137] © 2020 MedReviews®, LLC