Volume 18, Number 2Review ArticlesChallenges and Opportunities in Radiation-induced Hemorrhagic CystitisTherapeutic Strategy UpdateMichael B ChancellorBernadette MM ZwaansHeinz G NicolaiLaura E LambAs diagnosis and treatment of cancer is improving, medical and social issues related to cancer survivorship are becoming more prevalent. Hemorrhagic cystitis (HC), a rare but serious disease that may affect patients after pelvic radiation or systemic chemotherapy, has significant unmet medical needs. Although no definitive treatment is currently available, various interventions are employed for HC. Effects of nonsurgical treatments for HC are of modest success and studies aiming to control radiation-induced bladder symptoms are lacking. In this review, we present current and advanced therapeutic strategies for HC to help cancer survivors deal with long-term urologic health issues. [Rev Urol. 2016;18(2):57-65 doi: 10.3909/riu0700] © 2016 MedReviews®, LLCHemorrhagic cystitisRadiation-induced cystitisHematuriaCancer survivorship