Volume 3, Number 1Meeting ReviewsInternational Symposium on UTI ManagementAdvances in Urinary Tract Infection ManagementJ Curtis NickelPyelonephritisCystitisProstatitisUrinary tract infection (UTI)
Volume 5, Number 2Point-CounterpointManagement of Vesicoureteral RefluxEllen ShapiroMark ZaontzBrent SnowVesicoureteral refluxPyelonephritisHydronephrosisCross-trigonal repairDetrusorrhaphySubureteric injection
Volume 18, Number 1Case ReviewManagement of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid in AdultsTimothy W StarkJohn M LacyDavid M PrestonA 74-year-old man presented for evaluation after discovery of a left bladder-wall tumor. He underwent transurethral resection of bladder tumor (TURBT) operation for treatment of low-grade, Ta urothelial cancer of the bladder. The patient developed recurrent disease and returned to the operating room for repeat TURBT, circumcision, and administration of intravesical mitomycin C. The patient developed balanitis xerotica obliterans 4 years post-circumcision, requiring self-dilation with a catheter. He subsequently developed 3 consecutive episodes of left-sided pyelonephritis. Further investigation with voiding cystourethrogram (VCUG) revealed Grade 3, left-sided vesicoureteral reflux (VUR). Due to existing comorbidities, the patient elected treatment with endoscopic dextranomer/hyaluronic acid injection. A post-operative VCUG demonstrated complete resolution of left-sided VUR. This patient has remained symptom free for 8 months post-injection, with no episodes of pyelonephritis. [Rev Urol. 2016;18(1):46-50 doi: 10.3909/riu0689] © 2016 MedReviews®, LLCVesicoureteral refluxPyelonephritisDextranomer/hyaluronic acid
Volume 19, Number 4Review ArticlesA Head-to-Head Comparative Phase II Study of Standard Urine Culture and Sensitivity Versus DNA Next-generation Sequencing Testing for Urinary Tract InfectionsOriginal ResearchVladimir MouravievDavid AlbalaMichael McDonaldDarian KamehMark E JohnsonTruls E Bjerklund JohansenMany studies have discussed clinical practice guidelines for the treatment of cystitis and pyelonephritis. Treatment of uncomplicated urinary tract infections (UTIs) can be based on empiric antibiotic therapy. For complicated or recurrent UTIs, therapy can be based on laboratory-controlled culture and sensitivity (C&S) reports. The diagnosis of UTI by clinical criteria alone has an error rate of up to 33%. In addition, positive laboratory culture results do not always indicate a diagnosis of UTI. Comparison of urine in a conventional culture model versus DNA next-generation sequencing (NGS) to accurately identify and provide information on resistance factors (mobile genetic elements) is warranted. Our study was a head-to-head comparative phase II study of standard urine C&S versus DNA NGS testing for the diagnosis and treatment efficacy in patients with symptoms of acute cystitis based on short-term outcomes. [Rev Urol. 2017;19(4):213–220 doi: 10.3909/riu0780] © 2018 MedReviews®, LLCUrinary tract infectionPyelonephritisCystitisDNA next-generation sequencing