Volume 20, Number 4Review ArticlesFocal Ablation of Prostate CancerTreatment UpdateHerbert LeporJames WysockSamuel GoldThe challenge to the urology community is to reduce the risks of screening and treatment by reducing the number of men undergoing unnecessary biopsy and whole-gland curative treatment of low-risk disease. There is compelling evidence that focal ablation of prostate cancer is truly minimally invasive and offers major functional advantages over whole-gland treatment. [Rev Urol. 2018;20(3):145–157 doi: 10.3909/riu0809] © 2019 MedReviews®, LLCProstate cancer screeningHigh-intensity focused ultrasoundIrreversible electroporationFocal ablationProstate cancer treatmentVascular targeted photodynamic therapy