Volume 1, Number 4Review ArticlesThe Role of Recombinant Erythropoietin in Men Undergoing Radial Retropubic ProstatectomyTreatment UpdateNirit RosenblumHerbert Lepor
Volume 11, Number 2Review ArticlesWill the Evolution of Overactive Bladder Delivery Systems Increase Patient Compliance?Treatment ReviewNirit RosenblumThe negative impact of overactive bladder (OAB) on daily quality of life drives the large market of pharmacotherapy targeted at symptoms of urinary frequency and urgency, with or without urinary urge incontinence. Currently, the primary pharmacologic treatment modality is aimed at modulation of the efferent muscarinic receptors (M2 and M3) predominant in detrusor smooth muscle and responsible for involuntary or unwanted bladder contractions. However, due to drug effects in the muscarinic receptors of the salivary glands and intestinal smooth muscle, as well as extensive first-pass metabolism in the liver and intestinal tract yielding parent drug metabolites, adverse side effects are common and can be quite bothersome. These issues, encountered with many of the oral antimuscarinic formulations, limit their tolerability and affect long-term patient compliance and satisfaction. Thus, the benefit of pharmacotherapy for OAB must be a balance between efficacy and tolerability, also known as therapeutic index. This article reviews the current pharmacologic delivery systems available for the treatment of OAB, patient compliance, and reasons for discontinuation of medication.[Rev Urol. 2009;11(2):45-51]Overactive bladderPharmacotherapyComplianceAntimuscarinic agent
Volume 19, Number 2NYU Case of the MonthPelvic Organ Prolapse: Considerations in Surgical ManagementApril 2017Nirit Rosenblum[Rev Urol. 2017;19(2):134–137 doi: 10.3909/riu0759] © 2017 MedReviews®, LLC
Volume 22, Number 4NYU Case of the MonthUpdate in Female Hormonal Therapy: What the Urologist Should KnowNYU Case of the Month, December 2020Nirit Rosenblum[Rev Urol. 2020;22(4):182–185] © 2021 MedReviews®, LLC