Volume 14, Number 3Book Reviewsa-Blockers for the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Update on Current Clinical EvidenceTreatment UpdateJ Curtis NickelNaji ToumaThe pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is multifactorial, making its treatment difficult. Multimodal therapy including a- adrenergic antagonists (a-blockers), anti-inflammatory agents, and other pain treatments may provide optimal management for CP/CPPS. Although a-blockers are the most prescribed drugs for patients with CP/CPPS, not all studies support their efficacy. A recent meta-analysis of small trials suggested that treatment with a-blockers, possibly in combination with antibacterial agents, is efficacious in relieving symptoms. Third-generation a1A blockers (silodosin, tamsulosin) may provide efficacy as well as reduced cardiovascular side effects. Future research should aim to identify potential biomarkers associated with treatment response. [Rev Urol. 2012;14(3/4):56-64 doi: 10.3909/riu0557] © 2013 MedReviews®, LLCAdrenergic alpha-1 receptor antagonistsTamsulosinSilodosinAlfuzosinProstatitis