Volume 8, Supplement 1Review ArticlesContrast-Enhanced Ultrasound Imaging of Prostate CancerProstate Cancer ImagingEthan J HalpernUltrasound imaging of the prostate is commonly used to assess the size of the gland and for needle placement during systematic biopsy. Ultrasound evaluation of prostate cancer is limited by difficulty in distinguishing benign from malignant tissue. Although Doppler techniques may provide some improvement in the detection of prostate cancer, targeted biopsy based on conventional ultrasound with Doppler is not sufficient to replace systematic biopsy. Contrast-enhanced ultrasound imaging techniques that employ microbubble contrast agents represent an innovative approach to imaging of the neovascularity associated with prostate cancer. This review describes the application of contrast-enhanced ultrasound to improve detection and assessment of prostate cancer. [Rev Urol. 2006;8(suppl 1):S29-S37]Prostate cancerDopplerUltrasoundMicrobubble contrast agents