Editorial Board About Us

Christopher P Smith

All articles from this author are listed below.

Volume 4, Number 2 Review Articles

Botulinum Toxin: Poisoning the Spastic Bladder and Urethra

Treatment Update

George T Somogyi Christopher P Smith Michael B Chancellor

Pathophysiology Acetylcholine Detrusor hyperreflexia Detrusor external

Volume 12, Number 3 Review Articles

Surgical Options for Drug-Refractory Overactive Bladder Patients

Treatment Update

Jonathan S Starkman Christopher P Smith David R Staskin

Overactive bladder (OAB) is a symptom complex of urinary frequency, urinary urgency, and nocturia, with or without urgency incontinence. This syndrome is idiopathic in most instances without clearly defined pathophysiology. Studies clearly show that OAB negatively impacts health-related quality of life and impairs daily functioning in a large proportion of patients. Despite recent advances in drug delivery and improved tolerability of antimuscarinic drug class, a large percentage of patients remain refractory to conventional pharmacological therapy for this chronic condition. There are several unique and effective treatments that are available for this difficult population. We review the various surgical options within the urological armamentarium to treat patients with refractory OAB. [Rev Urol. 2010;12(2/3):e97-e110 doi:10.3909/riu0468]