Volume 17, Number 4Review ArticlesCan Serum Testosterone Be Used as a Marker of Overall Health?Health Screening UpdateMichael A MederosAaron M BernieJason M ScovellRanjith RamasamyLow serum testosterone has been associated with obesity, type 2 diabetes, metabolic syndrome, and atherosclerosis. Individuals with these comorbidities are at increased risk of premature death and other adverse health effects. Clinical data portend low testosterone as a risk factor for developing these conditions which are supported by the hypogonadal-obesity-adipocytokine hypothesis. The authors support comprehensive evaluation for these comorbid conditions in men found to have low serum testosterone. [Rev Urol. 2015;17(4):226-230 doi: 10.3909/riu0674] © 2016 MedReviews®, LLCDiabetesAndrogen deficiencyAging maleComorbiditiesCardiovascular disease